资 源 简 介
Both paired end whole transcriptome shotgun sequencing (RNA-Seq), and paired end Whole Genome Shotgun Sequencing (WGSS), can be used to discover rearrangements in tumour genomes. Comrad is a novel algorithmic framework for the integrated analysis of RNA-Seq and WGSS data for the purposes of discovering genomic rearrangements and aberrant transcripts. The Comrad framework leverages the advantages of both RNA-Seq and WGSS data, providing accurate classi cation of rearrangements as expressed or not expressed and accurate classi cation of the genomic or non-genomic origin of aberrant transcripts. A major bene t of Comrad is its ability to accurately identify aberrant transcripts and associated rearrangements using low coverage genome data. As a result, a Comrad analysis can be performed at a cost comparable to that of two RNA-Seq experiments, signi cantly lower than an analysis requiring high coverage genome data.
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