资 源 简 介
ProbTF is a software tool for predicting transcription factor binding using experimentally verified Position Weight Matrices (PWMs). The included sets of PWMs are from the TRANSFAC Public 7.0 database
ProbTF provides a probabilistic framework for transcription factor binding prediction which has three important features. First, ProbTF is probabilistic in nature and thus outputs a probability of binding (as opposed to a p-value). Second, the method answers the question of whether the whole promoter has a binding site. Third, ProbTF provides a principled way of combining multiple data sources, such as evolutionary conservation, regulatory potential, CpG islands, nucleosome positioning, DNase hypersensitive sites, ChIP-chip, and other prior knowledge, into a unified probabilistic framework.
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